Abstract | OBJECTIVE: METHODS: RESULTS: There were 7 males and 7 females in each group (U-500 + metformin and U-500 + metformin + exenatide). Overall, U-500 insulin + metformin, either alone or with the addition of exenatide, resulted in a significant improvement in HbA1c in both groups, with no significant difference between the 2 groups. There was no meaningful weight change in those utilizing exenatide. Those on U-500 insulin and metformin alone had a tendency toward some weight gain. No severe hypoglycemia occurred during the study period. Symptomatic hypoglycemia was more common in the group on exenatide, but this occurred in only 5 patients, and the clinical significance of this is uncertain. Insulin dosage changes on U-500 regular insulin were variable but tended to be lower in those subjects on exenatide. CONCLUSIONS:
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Authors | Larry A Distiller, Hendrik Nortje, Holger Wellmann, Aslam Amod, Landman Lombard |
Journal | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
(Endocr Pract)
Vol. 20
Issue 11
Pg. 1143-50
(Nov 2014)
ISSN: 1530-891X [Print] United States |
PMID | 24936555
(Publication Type: Journal Article)
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