Abstract | PURPOSE: Favorable outcome after cataract surgery depends on proper control of the inflammatory response induced by cataract surgery. Pseudophakic cystoid macular edema is an important cause of visual decline after uncomplicated cataract surgery. DESIGN: PARTICIPANTS: Patients undergoing uncomplicated surgery for age-related cataract. METHODS: MAIN OUTCOME MEASURES: RESULTS: Fifteen randomized trials were identified. Postoperative inflammation was less in patients randomized to NSAIDs. The prevalence of PCME was significantly higher in the steroid group than in the NSAID group: 3.8% versus 25.3% of patients, risk ratio 5.35 (95% confidence interval, 2.94-9.76). There was no statistically significant difference in the number of adverse events in the 2 treatment groups. CONCLUSIONS: We found low to moderate quality of evidence that topical NSAIDs are more effective in controlling postoperative inflammation after cataract surgery. We found high-quality evidence that topical NSAIDs are more effective than topical steroids in preventing PCME. The use of topical NSAIDs was not associated with an increased events. We recommend using topical NSAIDs to prevent inflammation and PCME after routine cataract surgery.
|
Authors | Line Kessel, Britta Tendal, Karsten Juhl Jørgensen, Ditte Erngaard, Per Flesner, Jens Lundgaard Andresen, Jesper Hjortdal |
Journal | Ophthalmology
(Ophthalmology)
Vol. 121
Issue 10
Pg. 1915-24
(Oct 2014)
ISSN: 1549-4713 [Electronic] United States |
PMID | 24935281
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review, Systematic Review)
|
Copyright | Copyright © 2014 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
|
Topics |
- Anti-Inflammatory Agents
(therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Cataract Extraction
(adverse effects)
- Humans
- Macular Edema
(prevention & control)
- Postoperative Complications
(prevention & control)
- Randomized Controlled Trials as Topic
|