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Valvular heart disease associated with long-term treatment by methysergide: a case report.

Abstract
This case report concerns a woman treated continuously since at least 10 years by methysergide for cluster headache. The echocardiographic and histological features of the severe valve fibrosis presented by this patient are very similar to those described with 5 HT(2B) receptors agonistic drugs.
AuthorsMichel Andréjak, Catherine Szymanski, Sylvestre Maréchaux, Elise Arnalsteen, Valérie Gras, Jean-Paul Rémadi, Christophe Tribouilloy
JournalTherapie (Therapie) 2014 May-Jun Vol. 69 Issue 3 Pg. 255-7 ISSN: 0040-5957 [Print] France
PMID24934823 (Publication Type: Case Reports, Journal Article)
Copyright© 2014 Société Française de Pharmacologie et de Thérapeutique.
Chemical References
  • Serotonin Antagonists
  • Methysergide
Topics
  • Cluster Headache (drug therapy)
  • Female
  • Fibrosis
  • Heart Valve Diseases (chemically induced, physiopathology)
  • Humans
  • Methysergide (administration & dosage, adverse effects)
  • Middle Aged
  • Serotonin Antagonists (administration & dosage, adverse effects)
  • Severity of Illness Index
  • Time Factors

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