Abstract |
A new compound, named banganxanthone C (=12-(1,1-dimethylprop-2-en-1-yl)-5,10-dihydroxy-9-methoxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one; 4), together with five known compounds, were isolated from the leaves of Garcinia polyantha. The structures of the compounds were elucidated on the basis of 1D- and 2D-NMR spectroscopy. Among the known compounds, two were xanthones, one was a pentacyclic triterpene, one sterol, and one benzophenone derivative. Isoxanthochymol (2) and 4-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one (3) exhibited significant antiproliferative activity against the leukemia cell line TPH-1 with IC50 inhibition values of 1.5 and 2.8 μg/ml, respectively. The cytotoxic activity was found to be related to apoptosis induction.
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Authors | Alain Meli Lannang, Simplice J N Tatsimo, Hugues Fouotsa, Jean Paul Dzoyem, Ajit Kumar Saxena, Norbert Sewald |
Journal | Chemistry & biodiversity
(Chem Biodivers)
Vol. 11
Issue 6
Pg. 975-81
(Jun 2014)
ISSN: 1612-1880 [Electronic] Switzerland |
PMID | 24934683
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich. |
Chemical References |
- Antineoplastic Agents, Phytogenic
- Heterocyclic Compounds, 4 or More Rings
- Xanthones
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Topics |
- Antineoplastic Agents, Phytogenic
(chemistry, isolation & purification, pharmacology, toxicity)
- Apoptosis
(drug effects)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Clusiaceae
(chemistry)
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- HeLa Cells
- Heterocyclic Compounds, 4 or More Rings
(chemistry, isolation & purification, pharmacology, toxicity)
- Humans
- Inhibitory Concentration 50
- MCF-7 Cells
- Molecular Structure
- Plant Leaves
(chemistry)
- Structure-Activity Relationship
- Xanthones
(chemistry, isolation & purification, pharmacology, toxicity)
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