Cytotoxic compounds from the leaves of Garcinia polyantha.

Abstract

A new compound, named banganxanthone C (=12-(1,1-dimethylprop-2-en-1-yl)-5,10-dihydroxy-9-methoxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one; 4), together with five known compounds, were isolated from the leaves of Garcinia polyantha. The structures of the compounds were elucidated on the basis of 1D- and 2D-NMR spectroscopy. Among the known compounds, two were xanthones, one was a pentacyclic triterpene, one sterol, and one benzophenone derivative. Isoxanthochymol (2) and 4-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one (3) exhibited significant antiproliferative activity against the leukemia cell line TPH-1 with IC50 inhibition values of 1.5 and 2.8 μg/ml, respectively. The cytotoxic activity was found to be related to apoptosis induction.

• Authors: Alain Meli Lannang, Simplice J N Tatsimo, Hugues Fouotsa, Jean Paul Dzoyem, Ajit Kumar Saxena, Norbert Sewald
• Journal: Chemistry & biodiversity (Chem Biodivers) Vol. 11 Issue 6 Pg. 975-81 (Jun 2014) ISSN: 1612-1880 [Electronic] Switzerland
• PMID: 24934683 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich.

Chemical References

• Antineoplastic Agents, Phytogenic
• Heterocyclic Compounds, 4 or More Rings
• Xanthones

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology, toxicity)
• Apoptosis (drug effects)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Clusiaceae (chemistry)
• Dose-Response Relationship, Drug
• Drug Screening Assays, Antitumor
• HeLa Cells
• Heterocyclic Compounds, 4 or More Rings (chemistry, isolation & purification, pharmacology, toxicity)
• Humans
• Inhibitory Concentration 50
• MCF-7 Cells
• Molecular Structure
• Plant Leaves (chemistry)
• Structure-Activity Relationship
• Xanthones (chemistry, isolation & purification, pharmacology, toxicity)