Abstract | PURPOSE: METHODS: RESULTS: In HL-60 cells, CBSLN induced a higher and prolonged expression level of the butyrate target genes at lower concentrations than NB. This led to a significant decrease in cell proliferation, along with considerable apoptosis, cell cycle block in the G0/G1 phase, significant inhibition of total HD activity and overexpression of the p21 protein. Conversely, in MCF-7 cells, CBSLN did not enhance the level of expression of the butyrate target genes, leading to the same anticancer activity as that of NB. CONCLUSIONS: Solid lipid nanoparticles were able to improve butyrate anticancer activity in HL-60, but not in MCF-7 cells. This is consistent with difference in properties of the cells under study, such as expression of the TP53 tumor suppressor, or the transporter for short-chain fatty acids, SLC5A8.
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Authors | Federica Foglietta, Loredana Serpe, Roberto Canaparo, Nicoletta Vivenza, Giovanna Riccio, Erica Imbalzano, Paolo Gasco, Gian Paolo Zara |
Journal | Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
(J Pharm Pharm Sci)
Vol. 17
Issue 2
Pg. 231-47
( 2014)
ISSN: 1482-1826 [Electronic] Canada |
PMID | 24934552
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Butyrates
- Histone Deacetylase Inhibitors
- Lipids
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Topics |
- Antineoplastic Agents
(administration & dosage, pharmacology)
- Breast Neoplasms
(pathology)
- Butyrates
(administration & dosage, pharmacology)
- Cell Proliferation
(drug effects)
- Dose-Response Relationship, Drug
- Drug Delivery Systems
- Drug Screening Assays, Antitumor
- HL-60 Cells
- Histone Deacetylase Inhibitors
(administration & dosage, pharmacology)
- Humans
- Leukemia
(pathology)
- Lipids
(administration & dosage, chemistry)
- MCF-7 Cells
- Nanoparticles
(administration & dosage, chemistry)
- Particle Size
- Structure-Activity Relationship
- Surface Properties
- Tumor Cells, Cultured
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