[Clinical usefulness of alpha-and beta-defensins in biological environments in patients with ulcerative colitis].

Abstract

OBJECTIVE:

To determine the dependence of alpha-and beta-defensins in biological environments and prevalence of inflammatory process, activity bei patienten ulcerative colitis (UC). MATERIALIEN UND METHODEN: The study was conducted on 63 patients with moderate activity UC and 25 practically healthy people. Depending on the extent of the gut was isolated by the three groups of patients: group 1 (n = 18)--distal form, group 2 (n = 24)--left-hand localization of pathological process and group 3 (n = 21)--total form UC. Content of beta-defensins in the stool and alpha-defensins in blood by method of the immune-enzyme analysis.

RESULTS:

In the control group the level of beta-defensins in the stool was 3.7 +/- 3.2 ng/g, alpha-defensins in blood--71.7 +/- 3.8 ng/ml. In patients of group 1 the concentration of beta-defensins in the stool was 218.5 +/- 8.2 ng/g in 2 group--210.8 +/- 4.3 ng/g and in group 3--261.7 +/- 9.2 ng/g. Intermediate level a-defensins in blood match in group 1--471.8 ğ 9.9 ng/ml in group 2--853.5 ğ 9.5 ng/ml and in group 3--479.3 +/- 6.8 ng/ ml. Regardless of the localization of lesions in the gut, not including beta-defensin in the stool at 2 under, the concentration of antimicrobial peptides in remission.

CONCLUSION:

Proven association increased expression of alpha-and beta-defensins with activity and a length of inflammation in the intestine at UC.

• Authors: M G Il'iashenko, G N Tarasova, D V Burtsev
• Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology (Eksp Klin Gastroenterol) Issue 9 Pg. 29-33 ( 2013) ISSN: 1682-8658 [Print] Russia (Federation)
• PMID: 24933962 (Publication Type: English Abstract, Journal Article)

Chemical References

• alpha-Defensins
• beta-Defensins

Topics

• Colitis, Ulcerative (blood)
• Feces
• Female
• Humans
• Male
• alpha-Defensins (blood)
• beta-Defensins (blood)