Abstract | AIMS: MAIN METHODS: KEY FINDINGS: The pentapeptide RM-131 increased gastric emptying in rodent models of ileus. RM-131 is about 100-fold more potent than human ghrelin and is 600 to 1800-fold more potent, when compared to several investigational ghrelin mimetics tested in clinical trials. RM-131 has anti-inflammatory effects and significantly increases survival and reduces macroscopic markers of tissue damage in a TNBS model of inflammatory bowel disease. RM-131 treatment shows a transient increase in growth hormone levels in Beagle dogs and rats, returning to baseline upon chronic treatment. Significant effects on glucose and insulin are not observed in chronic studies. SIGNIFICANCE:
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Authors | Lex Van der Ploeg, Haley Laken, Shubh Sharma, Rakesh Datta, Heather Halem, Jesse Dong, Caroline Touvay, Marc Teillot, Patrick Noonan, Lou Tartaglia, Liz Stoner, Bart Henderson, Keith Gottesdiener, Michael Culler |
Journal | Life sciences
(Life Sci)
Vol. 109
Issue 1
Pg. 20-9
(Jul 25 2014)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 24931905
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Gastrointestinal Agents
- Ghrelin
- Growth Hormone
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Topics |
- Animals
- Anti-Inflammatory Agents
(chemistry, therapeutic use)
- Diabetes Complications
(drug therapy)
- Dogs
- Gastric Emptying
(drug effects)
- Gastrointestinal Agents
(chemistry, therapeutic use)
- Gastrointestinal Diseases
(drug therapy)
- Gastrointestinal Motility
(drug effects)
- Gastroparesis
(drug therapy)
- Ghrelin
(chemistry, therapeutic use)
- Growth Hormone
(metabolism)
- Humans
- Ileus
(drug therapy)
- Inflammatory Bowel Diseases
(drug therapy)
- Male
- Mice
- Rats
- Rats, Sprague-Dawley
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