Intermittent clobazam prophylaxis in hot water epilepsy is safe and effective: a prospective study.

Abstract

PURPOSE:

To evaluate the role of intermittent prophylaxis with clobazam in the management of HWE in a long-term prospective study.

MATERIAL AND METHODS:

Two hundred and sixty patients [M:F - 194:66] with HWE were recruited. Patients were divided into: (a) 'HWE alone' (n=198) - received intermittent clobazam prophylaxis, 1-1½h prior to hot water head bath (group A); (b) 62 patients (20.4%) with 'HWE with spontaneous seizures were treated with continuous AEDs along with intermittent clobazam therapy (group B).

RESULTS:

Patients (n=198) in group A was followed for mean of 17.6 ± 10.6 months (range: 3-57). One hundred and forty seven patients (74.2%) had excellent response with complete seizure freedom with clobazam therapy while 12 (6.1%) had >75% reduction in seizure frequency. Remaining 39 (19.7%) required additional standard AED along with clobazam and 18 patients among them developed spontaneous/unprovoked seizure at follow up of 6.7 ± 4.1 months. Forty five patients in group B were seizure free while on continuous AEDs.

CONCLUSIONS:

Intermittent clobazam prophylaxis prior to head water bath might be a preferred mode of treatment of pure HWE. Additional AEDs are required if they have associated non-reflex unprovoked seizure.

• Authors: P Satishchandra, S Dilipkumar, D K Subbakrishna, S Sinha
• Journal: Epilepsy research (Epilepsy Res) Vol. 108 Issue 7 Pg. 1238-42 (Sep 2014) ISSN: 1872-6844 [Electronic] Netherlands
• PMID: 24929679 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Anticonvulsants
• Benzodiazepines
• Clobazam

Topics

• Adolescent
• Adult
• Anticonvulsants (therapeutic use)
• Benzodiazepines (therapeutic use)
• Child
• Child, Preschool
• Clobazam
• Electroencephalography
• Epilepsy (etiology, prevention & control)
• Female
• Follow-Up Studies
• Hot Temperature (adverse effects)
• Humans
• Male
• Prospective Studies
• Young Adult