Abstract | PURPOSE: METHODS AND RESULTS: We report on 12 patients with ARVC (mean age 40 ± 13 years) who were treated with ICD implantation in our center. Although several RV sites were tested for proper lead positions, the amplitude of R-wave at implantation was quite low (7.4 ± 3.0 mV). After a mean follow-up of 91 ± 28 months, R-wave amplitude significantly decreased to a mean value of 5.4 ± 2.5 mV (p=0.03). We also found a noticeable, nearly significant increase in pacing threshold (p=0.052) and a moderate increase in defibrillation impedance (p=0.07). Six patients (46 %) experienced at least one appropriate ICD therapy; three patients (23 %) experienced inappropriate ICD shocks secondary to the supraventricular tachycardia, T-wave oversensing, and electromagnetic interference. CONCLUSIONS: ICD in patients with ARVC has been demonstrated to be feasible and safe. In our case series, we found low R-wave amplitudes at implantation and a significant R-wave decrease during follow-up; a considerable and nearly significant increase in pacing threshold was also observed. These findings may be related to the progressive fibro-fatty replacement of RV myocardium. Multiple sites should be tested in the right ventricle if sensing or pacing values are not optimal, and all the electronic parameters should be carefully monitored throughout the entire follow-up.
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Authors | Giacomo Mugnai, Ruggero Tomei, Clementina Dugo, Luca Tomasi, Giovanni Morani, Corrado Vassanelli |
Journal | Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
(J Interv Card Electrophysiol)
Vol. 41
Issue 1
Pg. 23-9
(Oct 2014)
ISSN: 1572-8595 [Electronic] Netherlands |
PMID | 24928487
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Arrhythmogenic Right Ventricular Dysplasia
(complications, therapy)
- Defibrillators, Implantable
(adverse effects)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Treatment Outcome
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