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Evaluation of the neuroprotective activity of stansin 6, a resin glycoside from Ipomoea stans.

Abstract
Stansin 6 a tetrasaccharide resin glycoside isolated from the root of Ipomoea stans was evaluated as anticonvulsant and neuroprotective in kainic acid-induced seizures of rats. Intraperitoneal injection of kainic acid (10 mg/kg) induced typical behavioral seizures such as wet dog shakes and limbic seizures, and histopathological changes in the hippocampus (degeneration and loss of pyramidal cells in CA1 to CA4 areas). Stansin 6 (10-80 mg/kg) had no effect on the behavior of rats and did not induce hippocampal damage. Pretreatment with stansin 6 inhibited convulsions in rats from kainic acid-induced seizures, reduced the degeneration pattern in the CA3 region, decreased astrocytic reactivity, and reduced the expression of IL-1β and TNF-α induced by kainic acid. These results suggest that stansin 6 possesses neuroprotective and anticonvulsant activities.
AuthorsIsmael León-Rivera, Juana Villeda-Hernández, Victoria Campos-Peña, Alma Aguirre-Moreno, Samuel Estrada-Soto, Gabriel Navarrete-Vázquez, María Yolanda Rios, Berenice Aguilar-Guadarrama, Patricia Castillo-España, Julio César Rivera-Leyva
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 24 Issue 15 Pg. 3541-5 (Aug 01 2014) ISSN: 1464-3405 [Electronic] England
PMID24928403 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Anticonvulsants
  • Glycolipids
  • Neuroprotective Agents
  • stansin 6
  • Kainic Acid
Topics
  • Animals
  • Anticonvulsants (chemistry, isolation & purification, pharmacology)
  • Dogs
  • Dose-Response Relationship, Drug
  • Glycolipids (chemistry, isolation & purification, pharmacology)
  • Hippocampus (drug effects, pathology)
  • Ipomoea (chemistry)
  • Kainic Acid (administration & dosage)
  • Molecular Conformation
  • Neuroprotective Agents (chemistry, isolation & purification, pharmacology)
  • Plant Roots (chemistry)
  • Rats
  • Seizures (chemically induced, drug therapy)
  • Structure-Activity Relationship

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