Abstract | BACKGROUND AIMS: METHODS: Patients with MM who underwent ASCT between January 2008 and April 2011 at the Mount Sinai Medical Center were reviewed retrospectively. In April 2010, practice changes were instituted for patients with MM to delay initiation of granulocyte-colony-stimulating factor ( G-CSF) support from day 0 to day +5 and to add plerixafor to G-CSF as an up-front autologous mobilization. Targets of collection were 5-10 × 10(6) CD34(+) cells/kg. RESULTS: Of 50 adults with MM who underwent ASCT, 25 received plerixafor/ filgrastim and 25 received G-CSF alone as an up-front mobilization. Compared with the control, plerixafor mobilization yielded higher CD34(+) cell content (16.1 versus 8.4 × 10(6) CD34(+) cells/kg; P = 0.0007) and required fewer sessions of apheresis (1.9 versus 3.1; P = 0.0001). In the plerixafor group, the mean number of plerixafor doses required per patient was 1.8. Although the overall cost of medications was higher in the plerixafor group, the cost for blood products and overall cost of hospitalization were similar between the two groups. CONCLUSIONS: Up-front use of plerixafor is an effective mobilization strategy in patients with MM and does not have a substantial pharmacoeconomic impact in overall cost of hospitalization combined with the apheresis procedure.
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Authors | Sara S Kim, Anne S Renteria, Amir Steinberg, Karen Banoff, Luis Isola |
Journal | Cytotherapy
(Cytotherapy)
Vol. 16
Issue 11
Pg. 1584-1589
(Nov 2014)
ISSN: 1477-2566 [Electronic] England |
PMID | 24927717
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antigens, CD34
- Benzylamines
- Cyclams
- Heterocyclic Compounds
- plerixafor
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Topics |
- Adult
- Aged
- Antigens, CD34
(immunology)
- Benzylamines
- Cyclams
- Economics, Pharmaceutical
- Female
- Hematopoietic Stem Cell Mobilization
- Hematopoietic Stem Cell Transplantation
- Heterocyclic Compounds
- Humans
- Male
- Middle Aged
- Multiple Myeloma
(economics, pathology, therapy)
- Retrospective Studies
- Transplantation, Autologous
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