Hypoglycemic effect of Rhizophora mucronata in streptozotocin induced diabetic rats.

Rhizophora mucronata, plant of Mangroove family, found on the coastal region of India and used in treatment of various diseases. Different parts of plants are used in treatment of diabetes as folkloric medicine. The present study was designed to evaluate the hypoglycemic effect of hydro-alcoholic extract of R. mucronata. Streptozotocin (STZ)-induced diabetic rats were treated with RME (100 mg/kg and 200 mg/kg) and glibenclamide (0.5 mg/kg). Blood glucose levels were evaluated for the acute and sub-acute studies and body weight of rats were also monitored. All the treatments showed the highly significant (p<0.01) hypoglycemic effect in both the acute and the sub-acute studies. RME and glibenclamide treated rats were maintained the body weight during the study period while as the body weight of diabetic rats had gone down. The result of this study scientifically proved the hypoglycemic folkloric use of leaves of R. mucronata in treatment of diabetes.
AuthorsAwanish K Pandey, Prem P Gupta, Vijay K Lal
JournalJournal of complementary & integrative medicine (J Complement Integr Med) Vol. 11 Issue 3 Pg. 179-83 (Sep 2014) ISSN: 1553-3840 [Electronic] Germany
PMID24926628 (Publication Type: Journal Article)
Chemical References
  • Blood Glucose
  • Hypoglycemic Agents
  • Plant Extracts
  • Glyburide
  • Animals
  • Blood Glucose (metabolism)
  • Body Weight (drug effects)
  • Diabetes Mellitus, Experimental (blood, drug therapy)
  • Female
  • Glyburide (pharmacology, therapeutic use)
  • Hypoglycemic Agents (pharmacology, therapeutic use)
  • Male
  • Medicine, Traditional
  • Phytotherapy
  • Plant Extracts (pharmacology, therapeutic use)
  • Plant Leaves
  • Rats, Wistar
  • Rhizophoraceae

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