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Impact of tetrodotoxin application and lidocaine supplementation on equine jejunal smooth muscle contractility and activity of the enteric nervous system in vitro.

Abstract
By blocking the enteric nervous system (ENS) using tetrodotoxin (TTX), previous studies have documented the contractility-enhancing (CE) effects of lidocaine in equine intestinal smooth muscle (SM) at the level of SM cells and/or interstitial cells of Cajal (ICC). The present study examined the impact of ENS deactivation on CE lidocaine effects, and investigated the effects of lidocaine on ENS activity. TTX application did not affect the CE effects of lidocaine, indicating that these were not mediated by TTX-sensitive sodium channels. Application of TTX or ≥100 mg/L lidocaine reduced ENS activity. Although such concentrations of lidocaine exceed therapeutic blood concentrations, tissue concentrations may be higher with the potential to reduce ENS activity and impair intestinal motility in vivo. Improved understanding of underlying mechanisms is relevant for therapeutic use of lidocaine in horses with postoperative ileus.
AuthorsK Tappenbeck, S Hoppe, F Geburek, K Feige, K Huber
JournalVeterinary journal (London, England : 1997) (Vet J) Vol. 201 Issue 3 Pg. 423-6 (Sep 2014) ISSN: 1532-2971 [Electronic] England
PMID24923755 (Publication Type: Journal Article)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Sodium Channel Blockers
  • Voltage-Gated Sodium Channel Blockers
  • Tetrodotoxin
  • Lidocaine
Topics
  • Animals
  • Enteric Nervous System (drug effects, physiology)
  • Gastrointestinal Motility (drug effects)
  • Horses (physiology)
  • Interstitial Cells of Cajal (drug effects)
  • Jejunum (drug effects, physiology)
  • Lidocaine (pharmacology)
  • Muscle Contraction (drug effects)
  • Muscle, Smooth (drug effects, physiology)
  • Sodium Channel Blockers (pharmacology)
  • Tetrodotoxin (pharmacology)
  • Voltage-Gated Sodium Channel Blockers (pharmacology)

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