Preconditioning with hyperbaric oxygen in pancreaticoduodenectomy: a randomized double-blind pilot study.

Abstract

UNLABELLED:

In a prospective randomized double-blind study, we evaluated the post-operative biological and clinical effects of a single preoperative hyperbaric-treatment the day before surgery for pancreatic ductal adenocarcinoma.

PATIENTS AND METHODS:

Twenty one patients were randomized and divided into two groups: group-A (10 patients, 48%) were exposed to a HyperBaric Oxygen (HBO) session the day before intervention [Pre-Intervention Day (PID)], group-B (11 patients, 52%) breathed air for 40 min in a hyperbaric chamber pressurized to 1.15 ATA (placebo group). For all patients blood samples were obtained before HBO treatment or the placebo procedure (T0); at the end of HBO session or placebo procedure (T1); on the first post-operative day (POD)(T2) and on seventh POD(T3) day, measuring interleukin (IL)-1, IL-6, IL-8, IL-10, IL-12 and TNF-α, recording postoperative pancreatic fistula (POPF), biliary-fistula, fever, intra-abdominal abscess, bleeding, pulmonary complications, delayed gastric emptying and requirement for post-operative antibiotics. The results of the present pilot study suggest that a single preoperative hyperbaric oxygen treatment on the day before surgery may reduce the complication rate in pancreatic resection.

• Authors: Gerardo Bosco, Andrea Casarotto, Emanuele Nasole, Enrico Camporesi, Roberto Salvia, Francesco Giovinazzo, Sara Zanini, Giuseppe Malleo, Andrea Di Tano, Alessandro Rubini, Vincenzo Zanon, Devanand Mangar, Claudio Bassi
• Journal: Anticancer research (Anticancer Res) Vol. 34 Issue 6 Pg. 2899-906 (Jun 2014) ISSN: 1791-7530 [Electronic] Greece
• PMID: 24922652 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Cytokines

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Combined Modality Therapy
• Cytokines (metabolism)
• Double-Blind Method
• Female
• Follow-Up Studies
• Humans
• Hyperbaric Oxygenation
• Length of Stay
• Male
• Middle Aged
• Oxygen Inhalation Therapy
• Pancreatic Neoplasms (pathology, surgery)
• Pancreaticoduodenectomy
• Pilot Projects
• Postoperative Complications
• Prognosis
• Prospective Studies
• Young Adult