Abstract | PURPOSE: Design and synthesis of a tumor responsive nanoparticle-based system for imaging and treatment of various cancers. METHODS: RESULTS: Uniform, stable cancer-targeted nanoparticles (PEGylated water-soluble Mn3O4 NPs and NLCs) were synthesized. No signs of cyto-,genotoxicity and DNA damage were detected for nanoparticles that do not contain an anticancer drug. Entrapment of vemurafenib into nanoparticles significantly enhanced drug toxicity in cancer cells with targeted V600E mutation. The developed nanoparticles containing LHRH and MMP2 peptides showed preferential accumulation in primary and metastatic tumors increasing the MRI signal in mice with melanoma, lung and ovarian cancers. CONCLUSIONS: The proposed nanoparticle-based systems provide the foundation for building an integrated MRI diagnostic and therapeutic approach for various types of cancer.
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Authors | Ronak Savla, Olga B Garbuzenko, Suzie Chen, Lorna Rodriguez-Rodriguez, Tamara Minko |
Journal | Pharmaceutical research
(Pharm Res)
Vol. 31
Issue 12
Pg. 3487-502
(Dec 2014)
ISSN: 1573-904X [Electronic] United States |
PMID | 24919932
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Antibodies, Monoclonal
- Antineoplastic Agents
- Biocompatible Materials
- Contrast Media
- Drug Carriers
- Indoles
- Manganese Compounds
- Oxides
- Sulfonamides
- Vemurafenib
- manganese oxide
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Topics |
- Animals
- Antibodies, Monoclonal
(administration & dosage, therapeutic use)
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Biocompatible Materials
- Cell Survival
(drug effects)
- Contrast Media
(administration & dosage, chemistry)
- Drug Carriers
- Drug Delivery Systems
- Female
- Humans
- Indoles
(administration & dosage, therapeutic use)
- Lung Neoplasms
(diagnosis, drug therapy)
- Magnetic Resonance Imaging
(methods)
- Male
- Manganese Compounds
(chemistry)
- Melanoma
(diagnosis, drug therapy)
- Mice
- Nanoparticles
(chemistry)
- Ovarian Neoplasms
(diagnosis, drug therapy)
- Oxides
(chemistry)
- Sulfonamides
(administration & dosage, therapeutic use)
- Tissue Distribution
- Vemurafenib
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