Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates diabetes-induced renal damage through the advanced glycation end product-related pathway in db/db mice.

Abstract

This study was conducted to examine whether oligonol, a low-molecular-weight polyphenol derived from lychee fruit, has an ameliorative effect on diabetes-induced alterations, such as advanced glycation end product (AGE) formation or apoptosis in the kidneys of db/db mice with type 2 diabetes. Oligonol [10 or 20 mg/(kg body weight · d), orally] was administered every day for 8 wk to prediabetic db/db mice, and its effect was compared with vehicle-treated db/db and normal control mice (m/m). The administration of oligonol decreased the elevated renal glucose concentrations and reactive oxygen species in db/db mice (P < 0.05). The increased serum urea nitrogen and creatinine concentrations, which reflect renal dysfunction in db/db mice, were substantially lowered by oligonol. Oligonol reduced renal protein expression of NAD(P)H oxidase subunits (p22 phagocytic oxidase and NAD(P)H oxidase-4), AGEs (except for pentosidine), and c-Jun N-terminal kinase B-targeting proinflammatory tumor necrosis factor-α (P < 0.05). Oligonol improved the expressions of antiapoptotic [B-cell lymphoma protein 2 (Bcl-2) and survivin] and proapoptotic [Bcl-2-associated X protein, cytochrome c, and caspase-3] proteins in the kidneys of db/db mice (P < 0.05). In conclusion, these results provide important evidence that oligonol exhibits a pleiotropic effect on AGE formation and apoptosis-related variables, representing renoprotective effects against the development of diabetic complications in db/db mice with type 2 diabetes.

• Authors: Chan Hum Park, Takako Yokozawa, Jeong Sook Noh
• Journal: The Journal of nutrition (J Nutr) Vol. 144 Issue 8 Pg. 1150-7 (Aug 2014) ISSN: 1541-6100 [Electronic] United States
• PMID: 24919686 (Publication Type: Journal Article)
• Copyright: © 2014 American Society for Nutrition.

Chemical References

• Bax protein, mouse
• Birc5 protein, mouse
• Glycation End Products, Advanced
• Inhibitor of Apoptosis Proteins
• Phenols
• Plant Extracts
• Polyphenols
• Reactive Oxygen Species
• Repressor Proteins
• Survivin
• Tumor Necrosis Factor-alpha
• bcl-2-Associated X Protein
• oligonol
• Catechin
• Creatinine
• NADPH Oxidase 4
• NADPH Oxidases
• Nox4 protein, mouse
• JNK Mitogen-Activated Protein Kinases
• Casp3 protein, mouse
• Caspase 3

Topics

• Animals
• Apoptosis (drug effects)
• Blood Urea Nitrogen
• Caspase 3 (genetics, metabolism)
• Catechin (analogs & derivatives, pharmacology)
• Creatinine (blood, urine)
• Diabetes Mellitus, Type 2 (drug therapy)
• Fruit (chemistry)
• Glycation End Products, Advanced (metabolism)
• Inhibitor of Apoptosis Proteins (genetics, metabolism)
• JNK Mitogen-Activated Protein Kinases (genetics, metabolism)
• Kidney (drug effects, metabolism, physiopathology)
• Litchi (chemistry)
• Male
• Mice
• Mice, Inbred C57BL
• NADPH Oxidase 4
• NADPH Oxidases (genetics, metabolism)
• Organ Size (drug effects)
• Oxidative Stress (drug effects)
• Phenols (pharmacology)
• Plant Extracts (pharmacology)
• Polyphenols (pharmacology)
• Reactive Oxygen Species (metabolism)
• Repressor Proteins (genetics, metabolism)
• Survivin
• Tumor Necrosis Factor-alpha (genetics, metabolism)
• bcl-2-Associated X Protein (genetics, metabolism)