[Efficacy and tolerability of cefuroxime-axetil in infections of the upper respiratory tract. Comparative study with cefadroxil].

Cefuroxime-axetil is the first oral broad spectrum cephalosporin to be naturally stable in the presence of bêta-lactamases. The aim of this randomized trial was to evaluate the efficacy and safety of cefuroxime-axetil (250 mg twice daily after meal) with cefadroxil (1 g twice daily during meal) for the treatment of upper respiratory tract infection. In this study 150 patients were enrolled. Before treatment, the two groups were comparable. Clinical success was achieved for 94.3% of the patients treated with cefuroxime-axetil versus 90.4% for cefadroxil. Statistical significance was reached (p less than 0.05) concerning the number of days with facial pain for sinusitis (3 days for the cefuroxime-axetil treated group versus 4 days), the rate of normal tympanum at the second examination (58.3% vs 20% respectively) for otitis, and the number of day with painful dysphagia for tonsillitis (2.6 vs 3.8 days respectively). Cefuroxime-axetil was safe (a few advers events occurred, almost all gastro-intestinal). Cefuroxime-axetil is a safe and effective treatment of upper respiratory tract infections.
AuthorsG Dupuis, D Ebbo, A Evennou, M Pappo
JournalRevue de laryngologie - otologie - rhinologie (Rev Laryngol Otol Rhinol (Bord)) Vol. 110 Issue 1 Pg. 123-6 ( 1989) ISSN: 0035-1334 [Print] FRANCE
Vernacular TitleEfficacité et tolérance du céfuroxime-axetil dans les infections des voies aériennes supérieures et de leurs cavités annexes. Etude comparative au céfadroxil.
PMID2491707 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Prodrugs
  • Cefadroxil
  • cefuroxime axetil
  • Cefuroxime
  • Adolescent
  • Adult
  • Aged
  • Cefadroxil (adverse effects, therapeutic use)
  • Cefuroxime (adverse effects, analogs & derivatives, therapeutic use)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prodrugs (adverse effects, therapeutic use)
  • Respiratory Tract Infections (drug therapy)

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