Comparison of maternal and umbilical cord blood soluble lectin-like oxidized low-density lipoprotein receptor 1 levels in early- and late-onset preeclampsia.

Abstract

BACKGROUND:

The main purpose of this study was to determine the maternal and umbilical cord blood oxidized LDL (oxLDL) and soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in early- and late-onset preeclampsia (PE).

MATERIALS AND METHODS:

A case-control study was conducted in pregnant women with early-onset (before 34 weeks' gestation n = 19) and late-onset (after 34 weeks' gestation n = 22) PE compared to healthy normotensive pregnant controls (n = 44). Groups were compared for the maternal and umbilical cord plasma oxLDL and serum sLOX-1 levels.

RESULTS:

The mean maternal and umbilical cord serum sLOX-1 and plasma oxLDL levels were significantly increased in early- and late-onset PE compared to controls (p < 0.001). When early- and late-onset PE women were compared with serum sLOX-1 levels, the increase was more pronounced in early PE (p < 0.001). However, same comparison is not statistically significant in cord blood for oxLDL where as it is significantly higher in maternal blood for oxLDL in early-onset PE group. Maternal and cord blood oxLDL and sLOX-1 levels are positively correlated with each other; however, they are negatively correlated with fetal weight and gestational age.

CONCLUSIONS:

According to our results, maternal and umbilical cord blood levels of oxLDL and sLOX-1 were higher in preeclamptic pregnant. Thus, for the first time it has been shown that oxLDL and sLOX-1 levels were higher in fetal circulation as well as plasma of preeclamptic pregnant. However, sLOX-1 levels seem to be more implying than oxLDL for the differentiation of early and late preeclampsia.

• Authors: A Tuten, H Erman, G G Korkmaz, M Oncul, R Gelisgen, V Sozer, S Acıkgoz, G Simsek, H Uzun
• Journal: Archives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 290 Issue 5 Pg. 1007-13 (Nov 2014) ISSN: 1432-0711 [Electronic] Germany
• PMID: 24916561 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lipoproteins, LDL
• Scavenger Receptors, Class E
• oxidized low density lipoprotein

Topics

• Adult
• Blood Pressure
• Body Mass Index
• Case-Control Studies
• Enzyme-Linked Immunosorbent Assay
• Female
• Fetal Blood
• Fetal Weight
• Gestational Age
• Humans
• Lipoproteins, LDL (blood)
• Pre-Eclampsia (blood)
• Pregnancy
• Scavenger Receptors, Class E (blood)