[Estimation of glomerular filtration rate in adults with common variable immunodeficiency treated with intravenous immunoglobulin. What formula should we use?].

Abstract

BACKGROUND:

The common variable immunodeficiency (CVID) is characterized by absence of isohemagglutinins and two standard deviations of normal levels of immunoglobulins. His treatment includes administering immunoglobulin, more frequently intravenous (IVIG). A side effect is the possible severe renal insufficiency secondary to the use of preparations containing sucrose. These patients have weight loss, decreased muscle mass associated with gastrointestinal disorders and bronchiectasis that limit physical activity and other factors. There are different formulas for determining the glomerular filtration rate, we compared the most commonly used to determine the most appropriate in this population.

OBJECTIVE:

To determine the correlation between glomerular filtration rate using the MDRD formula, CKD-EPI and Cockcroft-Gault and that obtained through the urine creatinine clearance 24 h in patients with common variable immunodeficiency who are treated with IVIG.

PATIENTS AND METHOD:

A transversal, observational and descriptive study that included 19 patients with common variable immunodeficiency, 12 women and 7 men, mean age 36 years, was done. Descriptive statistics with mean, median, mode and standard deviation was used. To measure the concordance of the measurements for quantitative variables intraclass correlation coefficient was used and to determine the correlation between the stages of renal function with different formulas kappa index was calculated.

RESULTS:

The values of the intraclass correlation coefficient showed a good correlation between creatinine clearance in 24 h urine with CKDEPI, mediocre with MDRD and nil with the Cockroft-Gault formula.

CONCLUSIONS:

Glomerular filtration rate obtained with CKD-EPI proved to be partially most useful, with a good correlation in relation to urine creatinine clearance in 24 h. Its routine use is recommended over other formulas in common variable immunodeficiency patients with suspected renal disease secondary to the use of IVIG.

• Authors: Arturo Gaspar, Guadalupe Miranda, Eunice López, Karen Rodríguez, Nora Segura
• Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) (Rev Alerg Mex) 2014 Apr-Jun Vol. 61 Issue 2 Pg. 45-51 ISSN: 0002-5151 [Print] Mexico
• Vernacular Title: Estimación de la tasa de filtración glomerular en adultos con inmunodeficiencia común variable tratados con inmunoglobulina intravenosa. Qué fórmula utilizar?
• PMID: 24915615 (Publication Type: Comparative Study, English Abstract, Journal Article, Observational Study)

Chemical References

• Immunoglobulins, Intravenous

Topics

• Adult
• Common Variable Immunodeficiency (drug therapy, physiopathology)
• Cross-Sectional Studies
• Female
• Glomerular Filtration Rate
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Kidney Function Tests
• Male