Abstract | INTRODUCTION: PATIENTS AND METHODS: We measured thrombin generation in the presence and absence of thrombomodulin in patients with portal vein thrombosis (PVT, n=47), Budd-Chiari syndrome (BCS, n=15) and cirrhosis (n=24) and compared the results to those obtained from healthy controls (n=21). Fifteen patients with PVT and 10 patients with BCS were treated with warfarin and were compared to an equal number of patients with atrial fibrillation matched for prothrombin time-international normalized ratio. We assessed resistance to thrombomodulin by using ratios [marker measured in the presence/absence of thrombomodulin]. RESULTS: There were no differences in thrombin generation between patients on warfarin treatment and their controls. Cirrhotic patients generated more thrombin in the presence of thrombomodulin and exhibited thrombomodulin resistance compared to controls [p=0.006 for endogenous thrombin potential (ETP) and p<0.001 for peak thrombin and both ratios ETP and peak] and patients with non-cirrhotic PVT (p=0.001, p=0.006, p<0.001, p<0.001 for ETP, peak, ratio ETP, ratio peak, respectively). The patients with cirrhotic PVT exhibited higher ETP (p=0.044) and peak (p=0.02) in the presence of thrombomodulin than controls, as well as thrombomodulin resistance (ETP and peak ratios: p=0.001). CONCLUSIONS:
|
Authors | Roza Chaireti, Rupesh Rajani, Annika Bergquist, Tor Melin, Inga-Lill Friis-Liby, Marjo Kapraali, Stergios Kechagias, Tomas L Lindahl, Sven Almer |
Journal | Thrombosis research
(Thromb Res)
Vol. 134
Issue 2
Pg. 455-61
(Aug 2014)
ISSN: 1879-2472 [Electronic] United States |
PMID | 24913997
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Anticoagulants
- Thrombomodulin
- Warfarin
- Thrombin
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Anticoagulants
(therapeutic use)
- Blood Coagulation Tests
- Budd-Chiari Syndrome
(blood, complications, drug therapy, metabolism)
- Female
- Hemostasis
- Humans
- Liver
(blood supply, metabolism)
- Liver Cirrhosis
(blood, complications, drug therapy, metabolism)
- Male
- Middle Aged
- Splanchnic Circulation
- Thrombin
(metabolism)
- Thrombomodulin
(metabolism)
- Venous Thrombosis
(blood, complications, drug therapy, metabolism)
- Warfarin
(therapeutic use)
- Young Adult
|