Abstract | OBJECTIVE: DESIGN: Secondary analysis of a randomized controlled trial. SETTING: Five university hospitals in Finland. SAMPLE: A total of 236 women referred for HMB. METHODS: MAIN OUTCOME MEASURES: HRQoL was measured by the RAND 36-item health survey (RAND-36), 5-Dimensional EuroQol and two questionnaires of mental wellbeing. RESULTS: At baseline, 63 women (27%) were anemic and 140 (60%) were severely iron deficient ( ferritin <15 μg/L). Only 8% of the anemic women had taken iron supplementation. Twelve months after treatment hemoglobin had increased in both hemoglobin groups, but was still significantly lower (p < 0.001) in initially anemic women (128 g/L) compared with nonanemic women (136 g/L). Twelve months after treatment three domain scores of RAND-36 increased more (energy, p = 0.002; physical functioning, p = 0.04; social functioning, p = 0.05), and anxiety (p = 0.02) and depression scores (p = 0.002) decreased more in anemic compared with nonanemic women. Serum ferritin took 5 years to reach normal levels. CONCLUSIONS: Improved HRQoL after treatment of HMB is associated with correction of anemia. Clinicians should actively screen for anemia in women with HMB and emphasize early iron substitution as an integral part of treatment.
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Authors | Pirkko Peuranpää, Satu Heliövaara-Peippo, Ian Fraser, Jorma Paavonen, Ritva Hurskainen |
Journal | Acta obstetricia et gynecologica Scandinavica
(Acta Obstet Gynecol Scand)
Vol. 93
Issue 7
Pg. 654-60
(Jul 2014)
ISSN: 1600-0412 [Electronic] United States |
PMID | 24912842
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 Nordic Federation of Societies of Obstetrics and Gynecology. |
Chemical References |
- Contraceptive Agents, Female
- Hemoglobins
- Levonorgestrel
- Ferritins
- Iron
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Topics |
- Adult
- Anemia
(drug therapy, etiology, psychology)
- Anxiety
(diagnosis)
- Contraceptive Agents, Female
(administration & dosage)
- Depression
(diagnosis)
- Female
- Ferritins
(analysis)
- Follow-Up Studies
- Hemoglobins
(analysis)
- Humans
- Hysterectomy
(psychology)
- Intrauterine Devices, Medicated
- Iron
(therapeutic use)
- Iron Deficiencies
- Levonorgestrel
(administration & dosage)
- Linear Models
- Menorrhagia
(complications, drug therapy, surgery)
- Middle Aged
- Quality of Life
- Surveys and Questionnaires
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