[The efficacy of traditional Chinese medicin in animal model of lung injury induced by paraquat: a meta-analysis].

Abstract

OBJECTIVE:

To systematically review the effect of traditional Chinese medicine (TCM) in an animal model of lung injury induced by paraquat (PQ), and to provide a theoretical basis for future clinical trials.

METHODS:

The Wanfang, CNKI, VIP, PubMed/MEDLINE, EMBASE database (from January 1979 to September 2012) were searched. All papers concerning TCM in animal model of lung injury induced by PQ were retrieved. Study selection and data extraction were performed on the basis of Cochrane systematic review methods. Weighted mean difference (WMD) and 95% confidence interval (95%CI) with random effects model was adopted to investigate the effect of TCM on lung injury induced by PQ.

RESULTS:

Eighteen papers involving 1 188 rats met our criteria. Meta-analysis showed that TCM could improve the lung coefficiency (WMD -0.07, 95%CI -0.14 to -0.01, P=0.03), reduce lung wet/dry weight ratio (WMD -1.15, 95%CI -2.03 to -0.27, P=0.01), increase the serum superoxide dismutase (SOD) activity (WMD 56.08, 95%CI 23.46 to 88.70, P=0.000 8), improve plasma glutathione peroxidase (GSH-Px) level (WMD 26.64, 95%CI 18.95 to 34.33, P<0.000 01), and lower serum malondialdehyde(MDA) level (WMD -0.65, 95%CI -1.00 to -0.30, P=0.000 2), however there was no significant difference in the level of serum tumor necrosis factor-α (TNF-α) and hydroxyproline(HYP) level between TCM and controls (TNF-α: WMD -25.15, 95%CI -54.87 to 4.57, P=0.10; HYP: WMD -0.11, 95%CI -2.71 to 0.48, P=0.17).

CONCLUSIONS:

These findings demonstrate the efficacy of TCM in animal models of lung injury induced by PQ. However taking account of heterogeneity, the efficacy should be interpreted with caution.

• Authors: Lei Wang, Guangliang Hong, Dong Li, Xiao Chen, Wenwen Han, Zhongqiu Lu
• Journal: Zhonghua wei zhong bing ji jiu yi xue (Zhonghua Wei Zhong Bing Ji Jiu Yi Xue) Vol. 26 Issue 6 Pg. 399-404 (Jun 2014) ISSN: 2095-4352 [Print] China
• PMID: 24912638 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review)

Chemical References

• Drugs, Chinese Herbal
• Paraquat

Topics

• Acute Lung Injury (chemically induced, drug therapy)
• Animals
• Disease Models, Animal
• Drugs, Chinese Herbal (therapeutic use)
• Male
• Paraquat (poisoning)
• Rats
• Rats, Sprague-Dawley
• Rats, Wistar