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The effect of lipoate on anaerobic cysteine metabolism in erythrocytes of patients treated with peritoneal dialysis.

AbstractBACKGROUND:
The studies aimed to evaluate the changes in cysteine sulfur metabolism in erythrocytes of end-stage renal failure (ESRF) patients treated with continuous ambulatory peritoneal dialysis (CAPD) caused by a one-month lipoate (LA) supplementation at a daily dose of 600 mg.
METHODS:
The level of sulfane sulfur and activity of sulfurtransferases were determined in erythrocytes of CAPD patients and in the control group.
RESULTS:
The sulfane sulfur level in erythrocytes of CAPD patients did not differ compared with healthy volunteers but LA supplementation increased the reactive sulfur concentration. LA elevated also cystathionase activity.
CONCLUSIONS:
LA supplementation in ESRF patients treated with CAPD increases the sulfane sulfur level which indicates the augmentation of its antioxidant and regulatory properties.
AuthorsMałgorzata Iciek, Bernadeta Marcykiewicz, Anna Bilska-Wilkosz, Maria Sokołowska-Jeżewicz, Joanna Kłapcińska
JournalPharmacological reports : PR (Pharmacol Rep) Vol. 66 Issue 2 Pg. 325-8 (Apr 2014) ISSN: 2299-5684 [Electronic] Switzerland
PMID24911088 (Publication Type: Journal Article)
CopyrightCopyright © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
Chemical References
  • Thioctic Acid
  • Cysteine
Topics
  • Adult
  • Aged
  • Cysteine (metabolism)
  • Dietary Supplements
  • Erythrocytes (metabolism)
  • Female
  • Humans
  • Kidney Failure, Chronic (metabolism)
  • Male
  • Middle Aged
  • Peritoneal Dialysis, Continuous Ambulatory
  • Thioctic Acid (administration & dosage)

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