HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Mannose-binding lectin exon 1 and promoter polymorphisms in tuberculosis disease in a Mediterranean area.

Abstract
Mannose-binding lectin (MBL) is a serum protein that activates the complement and mediates phagocytosis. MBL levels and MBL2 genotype may impact upon host susceptibility to tuberculosis (TB) disease but evidence to date has been conflicting. MBL2 exon 1 and promoter genotyping and serum MBL concentrations were determined in 79 patients with active tuberculosis (58 pulmonary TB and 21 extrapulmonary or miliary TB) and 120 household healthy contacts (HHC) from a Mediterranean area (Majorca Island, Spain). Significantly higher serum MBL levels were found in patients with active tuberculosis than in HHC [median MBL concentrations 3430 ng mL(-1) (10-28 415) and 2600 ng mL(-1) (5-20 000) respectively, P = 0.002]. These higher MBL levels were mainly related to the most prevalent YA/YA wild-type diplotype. There was a strong correlation between MBL2 exon 1 and promoter genotype and MBL levels. The diplotype LYQA/HYPA was present in 12 out of 57 of the pulmonary TB cases but in none of the extrapulmonary TB patients. Diplotype LXPA/HYPA, producer of high levels of MBL, was significantly more frequent in HHC than in patients (16.8% vs. 6.4%, P = 0.031) suggesting a protective role against the development of TB disease that has not been previously found.
AuthorsM García-Gasalla, J Milá Llambí, I Losada-López, C Cifuentes-Luna, V Fernández-Baca, A Pareja-Bezares, I Mir-Villadrich, A Payeras-Cifré
JournalInternational journal of immunogenetics (Int J Immunogenet) Vol. 41 Issue 4 Pg. 306-11 (Aug 2014) ISSN: 1744-313X [Electronic] England
PMID24910008 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2014 John Wiley & Sons Ltd.
Chemical References
  • MBL2 protein, human
  • Mannose-Binding Lectin
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Exons (genetics)
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease (genetics)
  • Genotype
  • Haplotypes
  • Humans
  • Male
  • Mannose-Binding Lectin (blood, genetics)
  • Mediterranean Islands
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic (genetics)
  • Spain
  • Tuberculosis (blood, genetics)
  • Tuberculosis, Pulmonary (blood, genetics)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: