Abstract |
High fructose intake is associated with adverse metabolic syndromes. This study was designed to investigate whether the polysaccharides derived from Zizyphus jujube cv. Shaanbeitanzao (ZSP) could alleviate high fructose-induced insulin resistance and dyslipidemia in mice. ZSP was identified by capillary zone electrophoresis as an acidic heteropolysaccharide with l-arabinose, d-galactose and d-galacturonic acid being the main component monosaccharides. Mice were provided with 20% high- fructose water and ZSP was administered intragastrically at doses of 0, 200 or 400 mg kg(-1) BW for 4 weeks. Fructose-treated mice showed hyperglycemia, hyperinsulinemia and dyslipidemia with impaired insulin sensitivity (p < 0.05). Administration of ZSP at a dose of 400 mg kg(-1) BW significantly reduced the serum levels of glucose, insulin, TC, TG, LDL-C, and VLDL-C (p < 0.01). ZSP also markedly improved the HDL-C level, homeostasis model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β), and decreased the atherogenic index (AI) of the mice exposed to high- fructose water. Histopathological test with H&E and oil red O staining confirmed liver steatosis induced by a high- fructose diet and the hepatoprotective effect of ZSP. These findings indicate that the jujube polysaccharides may ameliorate insulin resistance and dyslipidemia in fructose-treated mice.
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Authors | Yan Zhao, Xingbin Yang, Daoyuan Ren, Dongying Wang, Yang Xuan |
Journal | Food & function
(Food Funct)
Vol. 5
Issue 8
Pg. 1771-8
(Aug 2014)
ISSN: 2042-650X [Electronic] England |
PMID | 24906476
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Hexuronic Acids
- Insulin
- Plant Extracts
- Polysaccharides
- Triglycerides
- Fructose
- galacturonic acid
- Arabinose
- Galactose
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Topics |
- Animals
- Arabinose
(metabolism)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Dose-Response Relationship, Drug
- Dyslipidemias
(prevention & control)
- Fatty Liver
(drug therapy)
- Fructose
(adverse effects)
- Galactose
(metabolism)
- Hexuronic Acids
(metabolism)
- Hyperglycemia
(drug therapy)
- Hyperinsulinism
(drug therapy)
- Insulin
(blood)
- Insulin Resistance
- Insulin-Secreting Cells
(metabolism)
- Male
- Mice
- Plant Extracts
(pharmacology)
- Polysaccharides
(pharmacology)
- Triglycerides
(blood)
- Ziziphus
(chemistry)
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