Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo.

Abstract

The present study is designed to investigate the protection by ferulic acid against the hepatotoxicity induced by diosbulbin B and its possible mechanism, and further observe whether ferulic acid augments diosbulbin B-induced anti-tumor activity. The results show that ferulic acid decreases diosbulbin B-increased serum alanine transaminase/aspartate transaminase (ALT/AST) levels. Ferulic acid also decreases lipid peroxide (LPO) levels which are elevated in diosbulbin B-treated mice. Histological evaluation of the liver demonstrates hydropic degeneration in diosbulbin B-treated mice, while ferulic acid reverses this injury. Moreover, the activities of copper- and zinc-containing superoxide dismutase (CuZn-SOD) and catalase (CAT) are decreased in the livers of diosbulbin B-treated mice, while ferulic acid reverses these decreases. Further results demonstrate that the mRNA expressions of CuZn-SOD and CAT in diosbulbin B-treated mouse liver are significantly decreased, while ferulic acid prevents this decrease. In addition, ferulic acid also augments diosbulbin B-induced tumor growth inhibition compared with diosbulbin B alone. Taken together, the present study shows that ferulic acid prevents diosbulbin B-induced liver injury via ameliorating diosbulbin B-induced liver oxidative stress injury and augments diosbulbin B-induced anti-tumor activity.

• Authors: Jun-ming Wang, Yu-chen Sheng, Li-li Ji, Zheng-tao Wang
• Journal: Journal of Zhejiang University. Science. B (J Zhejiang Univ Sci B) Vol. 15 Issue 6 Pg. 540-7 (Jun 2014) ISSN: 1862-1783 [Electronic] China
• PMID: 24903991 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Coumaric Acids
• Heterocyclic Compounds, 4 or More Rings
• Reactive Oxygen Species
• diosbulbin B
• ferulic acid

Topics

• Animals
• Antineoplastic Agents (administration & dosage, adverse effects)
• Cell Line, Tumor
• Chemical and Drug Induced Liver Injury (etiology, metabolism, prevention & control)
• Coumaric Acids (administration & dosage)
• Dose-Response Relationship, Drug
• Drug Synergism
• Heterocyclic Compounds, 4 or More Rings (administration & dosage, adverse effects)
• Male
• Mice
• Mice, Inbred ICR
• Oxidative Stress (drug effects)
• Reactive Oxygen Species (metabolism)
• Sarcoma (drug therapy, metabolism)
• Treatment Outcome