HLA-DRB1 and susceptibility to kidney allograft rejection in Southern Iranian patients.

Abstract

Kidney transplantation is the best treatment option for the patients with end-stage renal disease. Viral infections and genetic factors such as HLA-II antigens may affect the kidney transplant outcome. The compatibility of HLA-DRB1 molecules in the survival of kidney transplant is important. Also, the correlation between these molecules and viral infections is significant. The current study investigates the allele frequency of HLA-DRB1 in 41 recipient kidney transplant and 203 normal healthy controls by polymerase chain reaction using sequence specific primers. Moreover the relation between HLA-DRB1 allelic groups and hepatitis B, hepatitis C and cytomegalovirus viral infections was also studied. However statistical analysis of the allele frequencies didn't show any significant association between HLA-DRB1 allelic group distributions or sharing and susceptibility to acute kidney transplant rejection (P > 0.05). Comparing the allele frequencies between HLA-DRB1*14 and DRB1*04 allelic showed a significant difference in controls and patients (P = 0.03 and P = 0.05 respectively). The results of the present study also showed a significant association between possession of HLA-DRB1*07 allele in kidney transplant recipients and hepatitis C virus infection (P = 0.009). In conclusion however the results of the present study did not showed relation between HLA-DRB1 allele's frequencies or sharing and kidney transplantation outcome, the results indicated that HLA-DRB1 alleles may susceptible individuals to renal disease or play a role in susceptibility to viral infection in kidney transplant patients.

• Authors: Behrouz Gharesi-Fard, Leila Rezanezhad, Mohammad Hossein Karimi, Bita Geramizadeh, Mohammad Mehdi Salehipour, Seyed Ali Malek Hosseini, Jamshid Roozbeh
• Journal: Molecular biology reports (Mol Biol Rep) Vol. 41 Issue 8 Pg. 5513-8 (Aug 2014) ISSN: 1573-4978 [Electronic] Netherlands
• PMID: 24903971 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DRB1 Chains

Topics

• Adolescent
• Adult
• Alleles
• Case-Control Studies
• Child
• Cytomegalovirus Infections (complications)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Graft Rejection (genetics)
• HLA-DRB1 Chains (genetics)
• Hepatitis B (complications)
• Hepatitis C (complications)
• Humans
• Iran
• Kidney (pathology)
• Kidney Failure, Chronic (complications, surgery)
• Kidney Transplantation
• Male
• Young Adult