HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Adult offspring of high-fat diet-fed dams can have normal glucose tolerance and body composition.

Abstract
Maternal high-fat diet consumption and obesity have been shown to program long-term obesity and lead to impaired glucose tolerance in offspring. Many rodent studies, however, use non-purified, cereal-based diets as the control for purified high-fat diets. In this study, primiparous ICR mice were fed purified control diet (10-11 kcal% from fat of lard or butter origin) and lard (45 or 60 kcal% fat) or butter (32 or 60 kcal% fat)-based high-fat diets for 4 weeks before mating, throughout pregnancy, and for 2 weeks of nursing. Before mating, female mice fed the 32 and 60% butter-based high-fat diets exhibited impaired glucose tolerance but those females fed the lard-based diets showed normal glucose disposal following a glucose challenge. High-fat diet consumption by female mice of all groups decreased lean to fat mass ratios during the 4th week of diet treatment compared with those mice consuming the 10-11% fat diets. All females were bred to male mice and pregnancy and offspring outcomes were monitored. The body weight of pups born to 45% lard-fed dams was significantly increased before weaning, but only female offspring born to 32% butter-fed dams exhibited long-term body weight increases. Offspring glucose tolerance and body composition were measured for at least 1 year. Minimal, if any, differences were observed in the offspring parameters. These results suggest that many variables should be considered when designing future high-fat diet feeding and maternal obesity studies in mice.
AuthorsK M Platt, R J Charnigo, K J Pearson
JournalJournal of developmental origins of health and disease (J Dev Orig Health Dis) Vol. 5 Issue 3 Pg. 229-39 (Jun 2014) ISSN: 2040-1752 [Electronic] England
PMID24901663 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Blood Glucose
Topics
  • Age Factors
  • Animals
  • Blood Glucose (metabolism)
  • Body Composition (physiology)
  • Diet, High-Fat (adverse effects, trends)
  • Female
  • Glucose Intolerance (blood, chemically induced)
  • Glucose Tolerance Test (methods)
  • Male
  • Maternal Nutritional Physiological Phenomena (physiology)
  • Mice
  • Mice, Inbred ICR
  • Pregnancy
  • Random Allocation

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: