HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome.

Abstract
Selective inhibitors for the human immunoproteasome LMP7 (β5i) subunit over the constitutive proteasome hold promise for the treatment of autoimmune and inflammatory diseases and hematologic malignancies. Here we report that oxathiazolones inhibit the immunoproteasome β5i with up to 4700-fold selectivity over the constitutive proteasome, are cell permeable, and inhibit proteasomes inside cells.
AuthorsHao Fan, Nicholas G Angelo, J David Warren, Carl F Nathan, Gang Lin
JournalACS medicinal chemistry letters (ACS Med Chem Lett) Vol. 5 Issue 4 Pg. 405-10 (Apr 10 2014) ISSN: 1948-5875 [Print] United States
PMID24900849 (Publication Type: Journal Article)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: