Identification of aminopyridazine-derived antineuroinflammatory agents effective in an Alzheimer's mouse model.

Abstract

Targeting neuroinflammation may be a new strategy to combat Alzheimer's disease. An aminopyridazine 1b previously reported as a novel antineuroinflammatory agent was considered to have a potential therapeutic effect for Alzheimer's disease. In this study, we further explored the chemical space to identify more potent antineuroinflammatory agents and validate their in vivo efficacy in an animal model. Compound 14 was finally identified as an effective agent with comparable in vivo efficacy to the marketed drug donepezil in counteracting spatial learning and working memory impairment in an Aβ-induced Alzheimer's mouse model.

• Authors: Wei Zhou, Guifa Zhong, Xiurong Rao, Hui Xie, Shaogao Zeng, Tianyan Chi, Libo Zou, Donghai Wu, Wenhui Hu
• Journal: ACS medicinal chemistry letters (ACS Med Chem Lett) Vol. 3 Issue 11 Pg. 903-7 (Nov 08 2012) ISSN: 1948-5875 [Print] United States
• PMID: 24900405 (Publication Type: Journal Article)