Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS:
Manumycin treatment resulted in significant decreases in the viabilities of the two prostate cancer cell lines in a dose-dependent manner through apoptosis, and this apoptosis involved caspase-9 activation. A specific inhibitor of caspase-9 protected cells from caspase-3 activation, apoptosis, and cytotoxicity induced by manumycin. We also found that manumycin downregulated Bcl-2 expression and upregulated Bax expression. CONCLUSION:
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Authors | Jing-Gao Li, Miao-Rong She, Ci-Yong Lu, Shan-Shan Wei, Ping-Fang Xia, Ze-Sheng Lu, Qi Peng |
Journal | OncoTargets and therapy
(Onco Targets Ther)
Vol. 7
Pg. 771-7
( 2014)
ISSN: 1178-6930 [Print] New Zealand |
PMID | 24899815
(Publication Type: Journal Article)
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