Viscosupplementation with
hyaluronic acid is safe and effective in the management of
osteoarthritis, but its use in the treatment of tendon disorders has received less attention. The aim of this review is to summarize the current knowledge on this topic, evaluating experimental and clinical trials. A search of English-language articles was performed using the key search terms "
hyaluronic acid" or "
viscosupplementation" combined with "tendon," "
tendinopathy," "adhesions," or "gliding," independently. In quite all the experimental studies, performed after
surgical procedures for
tendon injuries or in the treatment of chronic
tendinopathies, using different
hyaluronic acid compounds, positive results (reduced formation of
scars and granulation tissue after tendon repair, less adhesions and gliding resistance, and improved tissue healing) were observed. In a limited number of cases,
hyaluronic acid has been employed in clinical practice. After flexor tendon surgery, a greater total active motion and fingers function, with an earlier return to work and daily activities, were observed. Similarly, in patients suffering from elbow, patellar, and shoulder tendons disorders,
pain was reduced, and function improved. The positive effect of
hyaluronic acid can be attributed to the anti-inflammatory activity, enhanced cell proliferation, and
collagen deposition, besides the lubricating action on the sliding surface of the tendon.