The purpose of this study was to evaluate the clinical application of strips containing 10%
Tetracycline (TC) in
periodontal disease. In this double blind study, placebo strips, which did not contain TC, were also prepared. Ninety-two sites in 46 cases with greater than a 4 mm
periodontal pocket were randomly assigned to experimental and control study groups. The following clinical parameters at each site were recorded at Weeks 0, 1, 2 and 3 after insertion of the
LSD or placebo strip: plaque and
calculus score, probing depth, gingival
inflammation (redness, swelling,
bleeding on probing,
pus discharge), mobility of the tooth,
pain on insertion of strip and
pain after the procedure. The residual quantity of TC in the
periodontal pocket was also determined at 1, 2 and 7 days after inserting the
LSD. All clinical data was evaluated using 3 types of statistical test (X2 test, Mann-Whitney's U test and Wilcoxon's test). Thus, the following results were obtained: 1. The
LSD group showed much improvement in clinical condition compared with the placebo group. 2. The conditions of
bleeding, redness or swelling of gingival tissue were much improved in the
LSD group, even after data evaluation with all 3 types of statistical test. 3. The residual quantity of TC was decreased day by day until finally it was not recognized in the 7 day samples. 4. This study suggested that the application of
LSD in the
periodontal pocket could be effective in periodontal treatment.