The characteristics of Bax inhibitor-1 and its related diseases.

Abstract

Bax inhibitor-1 (BI-1) is an evolutionarily-conserved endoplasmic reticulum protein. The expression of BI-1 in mammalian cells suppresses apoptosis induced by Bax, a pro-apoptotic member of the Bcl-2 family. BI-1 has been shown to be associated with calcium (Ca(2+)) levels, reactive oxygen species (ROS) production, cytosolic acidification, and autophagy as well as endoplasmic reticulum stress signaling pathways. According to both in vitro and clinical studies, BI-1 promotes the characteristics of cancers. In other diseases, BI-1 has also been shown to regulate insulin resistance, adipocyte differentiation, hepatic dysfunction and depression. However, the roles of BI-1 in these disease conditions are not fully consistent among studies. Until now, the molecular mechanisms of BI-1 have not directly explained with regard to how these conditions can be regulated. Therefore, this review investigates the physiological role of BI-1 through molecular mechanism studies and its application in various diseases.

• Authors: B Li, R K Yadav, G S Jeong, H-R Kim, H-J Chae
• Journal: Current molecular medicine (Curr Mol Med) Vol. 14 Issue 5 Pg. 603-15 ( 2014) ISSN: 1875-5666 [Electronic] Netherlands
• PMID: 24894176 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Apoptosis Regulatory Proteins
• Membrane Proteins
• Reactive Oxygen Species
• TMBIM6 protein, human

Topics

• Animals
• Apoptosis Regulatory Proteins (metabolism)
• Endoplasmic Reticulum Stress (physiology)
• Humans
• Lysosomes (metabolism)
• Membrane Proteins (metabolism)
• Models, Biological
• Reactive Oxygen Species (metabolism)
• Unfolded Protein Response (physiology)