Abstract | BACKGROUND:
Insulin resistance in horses is an emerging field of interest as it is thought to be a contributing factor in the pathogenesis of many equine conditions. OBJECTIVES: ANIMALS AND METHODS: Six 3-year-old healthy warmblood geldings were used. In a double blind 2 × 2 Latin square design at a dosage of 100 mg/kg body weight (BW)/day for 28 days the effects of oral supplementation of L-carnitine (as fumarate) were assessed. Glucose disposal and insulin sensitivity were measured by means of the euglycemic-hyperinsulinemic clamp technique. Radioimmunoassays were used to determine plasma leptin and insulin concentrations. Electrospray tandem mass spectrometry was used to assess acylcarnitines both in plasma and urine. Statistical analysis was performed using a linear mixed-effects model and P values <0.05 were considered significant. RESULTS: Long-term L-carnitine administration did not affect insulin sensitivity. Plasma leptin and free carnitine concentrations in plasma and urine increased significantly (P = 0.047 and 0.000, respectively) following L-carnitine administration as well as short-chain acylcarnitines in plasma and urinary excretion of short- and medium-chain acylcarnitines. CONCLUSION AND CLINICAL RELEVANCE: IMPACT FOR HUMAN MEDICINE:
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Authors | L C Kranenburg, C M Westermann, M G M de Sain-van der Velden, E de Graaf-Roelfsema, J Buyse, G P J Janssens, J van den Broek, J H van der Kolk |
Journal | The veterinary quarterly
(Vet Q)
Vol. 34
Issue 2
Pg. 85-91
( 2014)
ISSN: 1875-5941 [Electronic] England |
PMID | 24893614
(Publication Type: Journal Article)
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Chemical References |
- Leptin
- acylcarnitine
- Vitamin B Complex
- Carnitine
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Topics |
- Animals
- Carnitine
(administration & dosage, analogs & derivatives, blood, urine)
- Glucose Clamp Technique
(veterinary)
- Horses
(blood, urine)
- Insulin Resistance
- Leptin
(blood)
- Male
- Plasma
- Radioimmunoassay
(veterinary)
- Vitamin B Complex
(administration & dosage)
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