Protein kinase C inhibitors for immune disorders.

Abstract

Protein kinase C (PKC) proteins are a group of well-conserved, intracellular signaling enzymes expressed in all cells and tissues, including immune cells. Much of the molecular insight into PKC immunobiology has been gleaned from studies using PKC gene (Prkc) knockout mice and the analysis of different disease models in these animals. More-recent studies have revealed that PKCs also have crucial roles in the pathogenesis of human immune disorders. Therefore, strategies to modulate the functions of PKC enzymes could have a major impact on the treatment and therapies of autoimmune diseases and other immune disorders.

• Authors: Amnon Altman, Kok-Fai Kong
• Journal: Drug discovery today (Drug Discov Today) Vol. 19 Issue 8 Pg. 1217-21 (Aug 2014) ISSN: 1878-5832 [Electronic] England
• PMID: 24892801 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Protein Kinase Inhibitors
• Protein Kinase C

Topics

• Animals
• Humans
• Immune System Diseases (drug therapy, metabolism)
• Protein Kinase C (antagonists & inhibitors, metabolism)
• Protein Kinase Inhibitors (pharmacology, therapeutic use)