Abstract | OBJECTIVE: METHODS: The PubMed database was searched to identify and analyze relevant published reports. In particular, correlations between tumor-to-background ratio (TBR), standard uptake value (SUV) and histological response to chemotherapy were assessed. RESULTS: It was found that good responses are achieved in patients with TBR after chemotherapy (TBR2)/TBR before chemotherapy (TBR1) < 0.470 (positive predictive value [PPV] = 92.31%, negative predictive value [NPV] = 82.76%, sensitivity [S] = 87.80%, specificity [SP] = 88.89%), whereas poor responses occur in patients with SUV after chemotherapy/before chemotherapy (SUV2/SUV1) > 0.396 (PPV = 73.68%, NPV = 73.33%, S = 63.64%, SP = 81.48%). CONCLUSION: Changes in TBR are better predictors of chemotherapy response than SUV in osteosarcoma patients. Therefore, we believe that choice of surgical strategy is optimally based on changes in TBR.
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Authors | Jin-peng He, Yun Hao, Mi Li, Jiang Wang, Feng-jin Guo |
Journal | Orthopaedic surgery
(Orthop Surg)
Vol. 6
Issue 2
Pg. 145-53
(May 2014)
ISSN: 1757-7861 [Electronic] Australia |
PMID | 24890297
(Publication Type: Journal Article, Review)
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Copyright | © 2014 Chinese Orthopaedic Association and Wiley Publishing Asia Pty Ltd. |
Chemical References |
- Antineoplastic Agents
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
|
Topics |
- Antineoplastic Agents
(therapeutic use)
- Bone Neoplasms
(diagnostic imaging, drug therapy)
- Chemotherapy, Adjuvant
- Fluorodeoxyglucose F18
- Humans
- Multimodal Imaging
(methods)
- Osteosarcoma
(diagnostic imaging, drug therapy)
- Positron-Emission Tomography
(methods)
- Predictive Value of Tests
- Prognosis
- Radiopharmaceuticals
- Sensitivity and Specificity
- Tomography, X-Ray Computed
(methods)
- Treatment Outcome
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