Frequency of hereditary thrombophilia in women with recurrent pregnancy loss in Northern Pakistan.

Abstract

AIM:

Hereditary thrombophilia (HT) screening is performed as routine work-up of recurrent pregnancy loss (RPL) in Pakistan. In Northern Pakistan the prevalence of HT is not known. HT is not detected in the majority of RPL cases, especially in patients with ≤ 3 pregnancy losses (PL). The aim of this study was to determine the frequency of HT in women with RPL, and to find the prevalence of HT in patients with ≤ 3 PL and > 3 PL.

MATERIAL AND METHODS:

Lupus-anticoagulant-negative patients with unexplained RPL were screened for protein C, protein S, antithrombin, and factor V Leiden.

RESULTS:

A total of 315 patients with RPL were screened and 13 (4%) had evidence of HT. Protein C and protein S deficiency were detected in 6/140 (4.3%) women with > 3 PL and in 2/175 (1.1%) women with ≤ 3 PL. Antithrombin deficiency was detected in 2/140 (0.75%) women with > 3 PL and in no patients with ≤ 3 PL. Factor V Leiden was detected in 3/26 (12%) women with > 3 PL and in no patients with ≤ 3 PL. The prevalence of HT in patients with >3 PL was significantly higher than in patients with ≤ 3 PL (P = 0.002). We detected a strong association between HT and >3 PL (odds ratio 7.3; 95% confidence interval: 1.60-33.85) as compared to ≤ 3 PL.

CONCLUSION:

HT was detected in 4% of patients with RPL. The prevalence of HT in patients with > 3 PL is significantly higher than in patients with ≤ 3 PL.

• Authors: Nadir Ali, Farhat Abbas Bhatti, Saleem Ahmed Khan
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 40 Issue 6 Pg. 1561-6 (Jun 2014) ISSN: 1447-0756 [Electronic] Australia
• PMID: 24888916 (Publication Type: Journal Article)
• Copyright: © 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.

Topics

• Abortion, Habitual (genetics)
• Adolescent
• Adult
• Female
• Humans
• Pakistan (epidemiology)
• Pregnancy
• Prevalence
• Thrombophilia (complications, epidemiology)
• Young Adult