Abstract | INTRODUCTION: CASE PRESENTATION: A 39-year-old Caucasian woman with an invasive high-grade urothelial carcinoma presented with hematuria and low-grade fevers. Laboratory tests revealed an elevated white blood cell count and absolute neutrophil count and an elevated 24-hour urine protein. Upon further evaluation she was found to have locally advanced high-grade urothelial carcinoma without nodal or distant metastasis. Her serum granulocyte colony-stimulating factor level was 10 times the normal limit. This led to the diagnosis of a paraneoplastic leukemoid reaction. Her white blood cell count immediately normalized after cystectomy but increased in concordance with recurrence of her disease. Unfortunately, she rapidly progressed and expired within 10 months from the time of first diagnosis. CONCLUSIONS:
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Authors | Anup Kasi Loknath Kumar, Megha Teeka Satyan, Jeffrey Holzbeierlein, Moben Mirza, Peter Van Veldhuizen |
Journal | Journal of medical case reports
(J Med Case Rep)
Vol. 8
Pg. 147
(May 13 2014)
ISSN: 1752-1947 [Electronic] England |
PMID | 24885603
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Granulocyte Colony-Stimulating Factor
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Topics |
- Adult
- Autocrine Communication
- Carcinoma, Transitional Cell
(metabolism)
- Female
- Granulocyte Colony-Stimulating Factor
(metabolism)
- Humans
- Leukemoid Reaction
(etiology)
- Paraneoplastic Endocrine Syndromes
(complications)
- Urinary Bladder Neoplasms
(metabolism)
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