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Primary mucin-producing urothelial-type adenocarcinoma of the prostatic urethra diagnosed on TURP: a case report and review of literature.

AbstractBACKGROUND:
Mucin-producing urothelial-type adenocarcinoma of the prostatic urethra is extremely rare. These lesions must be differentiated from other mucinous tumors including mucin-producing prostatic adenocarcinoma and metastases from either colonic or bladder primaries.
CASE PRESENTATION:
We report here a case of urothelial-type adenocarcinoma arising from the prostatic urethra. The patient is an 81 year-old man with a history of pT1 urothelial cell carcinoma of the bladder status post trans-urethral resection of bladder tumor (TURBT) who initially presented with irritative lower urinary tract symptoms and mucosuria refractory to Flomax and finasteride. A shared decision was made for the patient to undergo trans-urethral resection of prostate (TURP). At the time of surgery, a papillary tumor emanating from the prostatic urethra was found and no urothelial lesions were noted in the bladder. Pathology of the resected prostatic chips revealed an invasive adenocarcinoma with intestinal-type differentiation that stained positive for CK7, CK20, and villin, but negative for PSA, PSAP, uroplakin, and CDX-2. Colonoscopy was normal and CT scan did not show any evidence of colonic lesions nor visceral or lymph node metastases. Thus, the patient was diagnosed with a primary urothelial-type adenocarcinoma of the prostatic urethra.
CONCLUSION:
Herein we review the literature regarding this unusual entity, and discuss the differential diagnosis, immunohistochemistry, and the importance of correctly identifying this rare tumor.
AuthorsElisabeth M Sebesta, Hossein S Mirheydar, J Kellogg Parsons, Jessica Wang-Rodriguez, A Karim Kader
JournalBMC urology (BMC Urol) Vol. 14 Pg. 39 (May 22 2014) ISSN: 1471-2490 [Electronic] England
PMID24885582 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Mucins
Topics
  • Adenocarcinoma (metabolism, pathology, surgery)
  • Aged, 80 and over
  • Diagnosis, Differential
  • Humans
  • Male
  • Mucins (metabolism)
  • Transurethral Resection of Prostate
  • Urethral Neoplasms (metabolism, pathology, surgery)

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