Abstract | BACKGROUND: CASE PRESENTATION: We report a 41 year-old Caucasian woman who received a lumbar methylprednisolone injection from a contaminated lot in August 2012. She was diagnosed with fungal meningitis by cerebrospinal fluid pleocytosis and positive (1, 3) beta- D-glucan after cultures and polymerase chain reaction were negative. Two weeks after onset of therapy, she developed a 4.1 mm superior cerebellar artery mycotic aneurysm associated with new stroke symptoms, which resolved with thirty-two weeks of antifungal treatment. CONCLUSIONS: This is the rare case report of successful medical management of a cerebral mycotic aneurysm with stroke symptoms related to a presumed phaeohyphomycosis in an immunocompetent individual. Further studies are needed to determine the utility of cerebrospinal fluid (1, 3) beta- D-glucan in diagnosing and monitoring patients with meningitis thought to be related to fungal infection.
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Authors | George Nelson, Olga Fermo, Kiran Thakur, Elizabeth Felton, Jee Bang, Lucy Wilson, Susan Rhee, Rafael Llinas, Kristine Johnson, David Sullivan |
Journal | BMC research notes
(BMC Res Notes)
Vol. 7
Pg. 327
(May 31 2014)
ISSN: 1756-0500 [Electronic] England |
PMID | 24885172
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antifungal Agents
- Voriconazole
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Topics |
- Adult
- Aneurysm
(complications, drug therapy)
- Antifungal Agents
(therapeutic use)
- Female
- Humans
- Meningitis, Fungal
(complications, drug therapy)
- Mycoses
(complications, drug therapy)
- Voriconazole
(therapeutic use)
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