Development of multi-organ involvement including a left atrial myxoma-like lesion in a patient with granulomatosis with polyangiitis.

Abstract

A 76-year-old woman suffering from granulomatosis with polyangitis (GPA) developed organizing pneumonia with positive antineutrophil cytoplasmic antibodies and microscopic hematuria. Prednisolone improved the hematuria and radiological findings; however, after tapering the dose of prednisolone, a posterior left atrial wall mass was detected in association with a fever. Both regressed spontaneously, although secretory otitis media and sinusitis were noted; the resected sinusitis specimen exhibited vasculitis highly suggestive of GPA. The clinical picture of GPA with multi-organ involvement can vary. Recognizing the various manifestations of GPA is therefore necessary in order to provide an appropriate diagnosis and disease management.

• Authors: Takashi Ishiguro, Noboru Takayanagi, Eriko Kawate, Yotaro Takaku, Naho Kagiyama, Yoshihiko Shimizu, Tsutomu Yanagisawa, Yutaka Sugita
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 53 Issue 11 Pg. 1143-7 ( 2014) ISSN: 1349-7235 [Electronic] Japan
• PMID: 24881738 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Prednisolone

Topics

• Aged
• Antibodies, Antineutrophil Cytoplasmic (blood)
• Diagnosis, Differential
• Echocardiography
• Female
• Granulomatosis with Polyangiitis (complications)
• Heart Diseases (diagnosis, etiology)
• Heart Neoplasms (diagnosis)
• Hematuria (etiology)
• Humans
• Lung (diagnostic imaging, pathology)
• Myxoma (diagnosis)
• Prednisolone (therapeutic use)
• Radiography