Abstract | UNLABELLED:
Allapinin, class 1C antiarrhythmic drug, is highly effective in treatment of patients with ventricular premature beats (VPB). The purpose of work was retrospective assessment of efficacy and safety of allapinin in patients with benign ventricular arrhythmias. 73 patients with VPB and no structural heart disease were selected from a database. In short course allapininin in dose of 75-150 mg per os daily decreased the number of VPB for more than 90% in 46,6% of patients. In 34,4% cases tolerable drug side effects were observed. Among patients with VPB burden of 10% and higher allapinin reduced this quantity below the indicated value in 76% of cases with tolerable drug side effects in 38,6% of cases. In long treatment study antiarrhythmic effect of allapinin persisted and no other side effects of the drug were documented. CONCLUSION:
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Authors | S F Sokolov, S A Bakalov, N A Mironova, M M Rogova, T A Malkina, S P Golitsyn |
Journal | Kardiologiia
(Kardiologiia)
Vol. 54
Issue 1
Pg. 20-6
( 2014)
ISSN: 0022-9040 [Print] Russia (Federation) |
PMID | 24881307
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anti-Arrhythmia Agents
- allapinin
- Aconitine
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Topics |
- Aconitine
(administration & dosage, analogs & derivatives, therapeutic use)
- Adolescent
- Adult
- Anti-Arrhythmia Agents
(administration & dosage, therapeutic use)
- Drug Administration Schedule
- Electrocardiography
- Female
- Humans
- Male
- Middle Aged
- Ventricular Premature Complexes
(drug therapy, physiopathology)
- Young Adult
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