[Effect of prostaglandin (PGE2) in biliary atresia].

Abstract

We studied the choleretic effect of Prostaglandin E2 (PGE2) in patients with biliary atresia. In the last four years PGE2 was used in ten cases with extrahepatic biliary atresia. All of them were treated by Kasai technique and temporary exteriorization of the bilioenteric conduit, permitting analyses of the postoperative bile flow. Mean age al operation was 50 days (range 30-70 days). The histology studies of liver and porta hepatis showed severe hepatic fibrosis in three patients, moderate in seven, bile ducts less than 100 mu in five and more than 100 mu in another five. The mean postoperative bile flow was 15 c.c./day (range 0-30 c.c.). We used PGE2 during postoperative period because the bile excretion was partial or total stopped (PGE2 0.125 mgr./kgr./day). In six cases the bile flow increase until 90 c.c./day (range 40-160 c.c./day) and four patients no response. Eight patients are alive, four without jaundice with normal hepatic function (serum bilirubin 1.04 mgr./dl) and four are waiting for liver transplantation. Two have died 7 and 30 months after Kasai procedure. The long-term follow-up was between 6 to 53 months. In conclusion the PGE2 has choleretic action in biliary atresia and could be a coadjuvant treatment to improve the bile flow.

• Authors: J M Gutiérrez, J Vázquez, M C Díaz, L Lassaletta, P Jara, J G Utrilla
• Journal: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica (Cir Pediatr) Vol. 2 Issue 4 Pg. 183-5 (Oct 1989) ISSN: 0214-1221 [Print] Spain
• Vernacular Title: Efecto de la prostaglandina (PGE2) en la atresia biliar.
• PMID: 2488078 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dinoprostone

Topics

• Biliary Atresia (drug therapy)
• Dinoprostone (therapeutic use)
• Follow-Up Studies
• Humans