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BRMS1 suppresses glioma progression by regulating invasion, migration and adhesion of glioma cells.

Abstract
Breast cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene in several solid tumors. However, the expression and function of BRMS1 in glioma have not been reported. In this study, we investigated whether BRMS1 play a role in glioma pathogenesis. Using the tissue microarray technology, we found that BRMS1 expression is significantly decreased in glioma compared with tumor adjacent normal brain tissue (P<0.01, χ(2) test) and reduced BRMS1 staining is associated with WHO stages (P<0.05, χ(2) test). We also found that BRMS1 was significantly downregulated in glioma cell lines compared to normal human astrocytes (P<0.01, χ(2) test). Furthermore, we demonstrated that BRMS1 overexpression inhibited glioma cell invasion by suppressing uPA, NF-κB, MMP-2 expression and MMP-2 enzyme activity. Moreover, our data showed that overexpression of BRMS1 inhibited glioma cell migration and adhesion capacity compared with the control group through the Src-FAK pathway. Taken together, this study suggested that BRMS1 has a role in glioma development and progression by regulating invasion, migration and adhesion activities of cancer cells.
AuthorsPengjin Mei, Jin Bai, Meilin Shi, Qinghua Liu, Zhonglin Li, Yuechao Fan, Junnian Zheng
JournalPloS one (PLoS One) Vol. 9 Issue 5 Pg. e98544 ( 2014) ISSN: 1932-6203 [Electronic] United States
PMID24879377 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Retracted Publication)
Chemical References
  • BRMS1 protein, human
  • NF-kappa B
  • Neoplasm Proteins
  • Repressor Proteins
  • Urokinase-Type Plasminogen Activator
  • Matrix Metalloproteinase 2
Topics
  • Astrocytes (metabolism, pathology)
  • Cell Adhesion (genetics)
  • Cell Line, Tumor
  • Cell Movement (genetics)
  • Disease Progression
  • Down-Regulation (genetics)
  • Female
  • Gene Expression Regulation, Neoplastic (genetics)
  • Genes, Tumor Suppressor (physiology)
  • Glioma (genetics, pathology)
  • Humans
  • Male
  • Matrix Metalloproteinase 2 (genetics)
  • Middle Aged
  • NF-kappa B (genetics)
  • Neoplasm Invasiveness (genetics)
  • Neoplasm Proteins (genetics)
  • Repressor Proteins
  • Urokinase-Type Plasminogen Activator (genetics)

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