Abstract |
Breast cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene in several solid tumors. However, the expression and function of BRMS1 in glioma have not been reported. In this study, we investigated whether BRMS1 play a role in glioma pathogenesis. Using the tissue microarray technology, we found that BRMS1 expression is significantly decreased in glioma compared with tumor adjacent normal brain tissue (P<0.01, χ(2) test) and reduced BRMS1 staining is associated with WHO stages (P<0.05, χ(2) test). We also found that BRMS1 was significantly downregulated in glioma cell lines compared to normal human astrocytes (P<0.01, χ(2) test). Furthermore, we demonstrated that BRMS1 overexpression inhibited glioma cell invasion by suppressing uPA, NF-κB, MMP-2 expression and MMP-2 enzyme activity. Moreover, our data showed that overexpression of BRMS1 inhibited glioma cell migration and adhesion capacity compared with the control group through the Src-FAK pathway. Taken together, this study suggested that BRMS1 has a role in glioma development and progression by regulating invasion, migration and adhesion activities of cancer cells.
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Authors | Pengjin Mei, Jin Bai, Meilin Shi, Qinghua Liu, Zhonglin Li, Yuechao Fan, Junnian Zheng |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 5
Pg. e98544
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24879377
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Retracted Publication)
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Chemical References |
- BRMS1 protein, human
- NF-kappa B
- Neoplasm Proteins
- Repressor Proteins
- Urokinase-Type Plasminogen Activator
- Matrix Metalloproteinase 2
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Topics |
- Astrocytes
(metabolism, pathology)
- Cell Adhesion
(genetics)
- Cell Line, Tumor
- Cell Movement
(genetics)
- Disease Progression
- Down-Regulation
(genetics)
- Female
- Gene Expression Regulation, Neoplastic
(genetics)
- Genes, Tumor Suppressor
(physiology)
- Glioma
(genetics, pathology)
- Humans
- Male
- Matrix Metalloproteinase 2
(genetics)
- Middle Aged
- NF-kappa B
(genetics)
- Neoplasm Invasiveness
(genetics)
- Neoplasm Proteins
(genetics)
- Repressor Proteins
- Urokinase-Type Plasminogen Activator
(genetics)
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