Ceftriaxone-induced hemolytic anemia: case report and review of literature.

Ceftriaxone is a frequently used empiric antibiotic in children. Acute hemolysis is a rare side effect of ceftriaxone therapy associated with a high mortality rate. A 14-year-old boy suffering from Crohn disease developed bacterial pneumonia that was treated with ceftriaxone. We report successful management of ceftriaxone-induced hemolytic anemia (CIHA) in this patient and review the CIHA literature in pediatric patients. Early recognition of CIHA with prompt discontinuation of ceftriaxone therapy may have a beneficial role in reduction of high mortality seen in these patients.
AuthorsMichael S Northrop, Hemant S Agarwal
JournalJournal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 37 Issue 1 Pg. e63-6 (Jan 2015) ISSN: 1536-3678 [Electronic] United States
PMID24878619 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Anti-Bacterial Agents
  • Ceftriaxone
  • Adolescent
  • Anemia, Hemolytic (chemically induced, therapy)
  • Anti-Bacterial Agents (adverse effects)
  • Ceftriaxone (adverse effects)
  • Humans
  • Male

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