Crinane alkaloids of the amaryllidaceae with cytotoxic effects in human cervical adenocarcinoma (HeLa) cells.

Abstract

The family Amaryllidaceae has a long history of usage in the traditional medicinal practices of the indigenous peoples of South Africa, with three of its species known to be used for cancer treatment. Furthermore, the Amaryllidaceae is widely recognized for its unique alkaloid constituents, several of which exhibit potent and selective cytotoxic activities. In this study, several crinane alkaloids derived from local Amaryllidaceae species were examined for cytotoxic effects against the human cervical adenocarcinoma cell line, of which distichamine was the most potent (IC50 2.2 microM).

• Authors: Jerald J Nair, Lucie Rárová, Miroslav Strnad, Jaume Bastida, Lee Cheesman, Johannes van Staden
• Journal: Natural product communications (Nat Prod Commun) Vol. 9 Issue 4 Pg. 461-6 (Apr 2014) ISSN: 1934-578X [Print] United States
• PMID: 24868855 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amaryllidaceae Alkaloids
• Cytotoxins

Topics

• Adenocarcinoma (drug therapy)
• Amaryllidaceae Alkaloids (chemistry, pharmacology)
• Cytotoxins (chemistry, pharmacology)
• Female
• HeLa Cells
• Humans
• Molecular Structure
• Uterine Cervical Neoplasms (drug therapy)