Abstract | OBJECTIVES: Candida albicans is a common fungal infection and is commensal in 40-65 % of healthy adults. The development and pharmacokinetics of a novel sustained release clotrimazole varnish (Clot-SRV) for topical oral use have been reported. The aim of this study was to compare the efficacy of this varnish with clotrimazole troche treatment of oral candidiasis. MATERIALS AND METHODS: Of the 12 patients with denture stomatitis treated for 14 days, six used Clot-SRV (study group) and six clotrimazole troches (control). The patients were instructed to use Clot-SRV (50 mg of clotrimazole) once a day, and the control group was instructed to use five troches of 10 mg clotrimazole/day. Microbiological samples were obtained from saliva, buccal mucosa, palate, and denture. The degree of erythema was recorded at three time points, and subjective opinions noted using a questionnaire. RESULTS: At the end of the study, the control group had relatively more cases of erythema on all examined surfaces; patients who applied the Clot-SRV had significantly lower levels of candida on the denture surfaces and in saliva, and had better compliance to the medication. CONCLUSIONS: The novel clotrimazole sustained release varnish may be an important part of a new protocol for oral candidiasis, with improved clinical outcomes.
|
Authors | Rakefet Czerninski, Anna Pikovsky, Irith Gati, Michael Friedman, Doron Steinberg |
Journal | Clinical oral investigations
(Clin Oral Investig)
Vol. 19
Issue 2
Pg. 467-73
(Mar 2015)
ISSN: 1436-3771 [Electronic] Germany |
PMID | 24867230
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antifungal Agents
- Delayed-Action Preparations
- Clotrimazole
|
Topics |
- Aged
- Animals
- Antifungal Agents
(administration & dosage, pharmacokinetics, therapeutic use)
- Candidiasis, Oral
(drug therapy)
- Clotrimazole
(administration & dosage, pharmacokinetics, therapeutic use)
- Delayed-Action Preparations
- Female
- Humans
- Middle Aged
- Rabbits
|