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Comparison of the efficacy of a novel sustained release clotrimazole varnish and clotrimazole troches for the treatment of oral candidiasis.

AbstractOBJECTIVES:
Candida albicans is a common fungal infection and is commensal in 40-65 % of healthy adults. The development and pharmacokinetics of a novel sustained release clotrimazole varnish (Clot-SRV) for topical oral use have been reported. The aim of this study was to compare the efficacy of this varnish with clotrimazole troche treatment of oral candidiasis.
MATERIALS AND METHODS:
Of the 12 patients with denture stomatitis treated for 14 days, six used Clot-SRV (study group) and six clotrimazole troches (control). The patients were instructed to use Clot-SRV (50 mg of clotrimazole) once a day, and the control group was instructed to use five troches of 10 mg clotrimazole/day. Microbiological samples were obtained from saliva, buccal mucosa, palate, and denture. The degree of erythema was recorded at three time points, and subjective opinions noted using a questionnaire.
RESULTS:
At the end of the study, the control group had relatively more cases of erythema on all examined surfaces; patients who applied the Clot-SRV had significantly lower levels of candida on the denture surfaces and in saliva, and had better compliance to the medication.
CONCLUSIONS:
The novel clotrimazole sustained release varnish may be an important part of a new protocol for oral candidiasis, with improved clinical outcomes.
AuthorsRakefet Czerninski, Anna Pikovsky, Irith Gati, Michael Friedman, Doron Steinberg
JournalClinical oral investigations (Clin Oral Investig) Vol. 19 Issue 2 Pg. 467-73 (Mar 2015) ISSN: 1436-3771 [Electronic] Germany
PMID24867230 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antifungal Agents
  • Delayed-Action Preparations
  • Clotrimazole
Topics
  • Aged
  • Animals
  • Antifungal Agents (administration & dosage, pharmacokinetics, therapeutic use)
  • Candidiasis, Oral (drug therapy)
  • Clotrimazole (administration & dosage, pharmacokinetics, therapeutic use)
  • Delayed-Action Preparations
  • Female
  • Humans
  • Middle Aged
  • Rabbits

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