Abstract | BACKGROUND: OBJECTIVE: This study aimed to evaluate the role of short-term prednisone therapy in improving left ventricular (LV) systolic function, LV mass (LVM), and motor power in cases of muscular dystrophies. PATIENTS AND METHODS: Twenty-five cases of muscular dystrophy including 17 cases of DMD, 3 cases of Becker muscular dystrophies, and 5 cases of female patients with DMD-like phenotype were included in the study. The diagnosis of 12 patients was confirmed by muscle biopsy with immunohistochemistry; the patients were subjected to motor assessment, measurement of creatine kinase level, and echocardiographic examination before and after prednisone therapy. Transthoracic echocardiographic assessment of the LV systolic function (fractional shortening) was done. Myocardial performance index and LVM were calculated. Intermittent dosage of prednisone was administered 5 mg/kg per day on 2 consecutive days weekly for 3 months. RESULTS: Fractional shortening improved on prednisone therapy (P = 0.009) and LVM increased (P = 0.012); improvement in walking was detected in 77% of the patients, climbing stairs improved in 88.9%, Gower sign improved in 70%, and rising from chair improved in 60%. Prednisone had no effect on the patients with marked motor impairment (on wheelchair). The creatine kinase level was significantly lower after steroid therapy (P = 0.04). CONCLUSIONS:
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Authors | Gehan Hussein, Lobna Mansour, Hadeer Abdel Ghafar, Fatma Alzahraa Mostafa, Lubna Fawaz |
Journal | Journal of investigative medicine : the official publication of the American Federation for Clinical Research
(J Investig Med)
Vol. 62
Issue 6
Pg. 875-9
(Aug 2014)
ISSN: 1708-8267 [Electronic] England |
PMID | 24866459
(Publication Type: Journal Article)
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Chemical References |
- Glucocorticoids
- Prednisone
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Topics |
- Adolescent
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Glucocorticoids
(administration & dosage)
- Humans
- Male
- Muscle, Skeletal
(diagnostic imaging, drug effects, physiology)
- Muscular Dystrophies
(drug therapy, physiopathology)
- Myocardium
- Prednisone
(administration & dosage)
- Prospective Studies
- Time Factors
- Treatment Outcome
- Ultrasonography
- Ventricular Function, Left
(drug effects, physiology)
- Walking
(physiology)
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