Abstract | BACKGROUND: METHODS: Adult male Wistar rats (n=26) were randomly assigned to one of the following four study groups: a control group that received no intervention; a periodontal disease group that received saline solution; a 'low dose' group that received 30 μg of budesonide daily; and a corresponding 'high dose' group that received 100 μg daily over a 15-day time course. The hydrolysis of ATP, ADP, and AMP were analysed in blood serum. RESULTS: CONCLUSION: The variables investigated in this study may be involved in the pathophysiology of periodontal disease and may participate in the mechanisms that mediate the development of some of the side effects of inhaled corticosteroids.
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Authors | Vanessa L Scarabelot, Juliano Cavagni, Liciane F Medeiros, Bernardo Detânico, Joanna R Rozisky, Andressa de Souza, Luciana Dondonis Daudt, Eduardo José Gaio, Maria Beatriz Cardoso Ferreira, Cassiano Kuchenbecker Rösing, Ana Maria O Battastini, Iraci L S Torres |
Journal | Archives of oral biology
(Arch Oral Biol)
Vol. 59
Issue 8
Pg. 841-7
(Aug 2014)
ISSN: 1879-1506 [Electronic] England |
PMID | 24863659
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Adenosine Monophosphate
- Budesonide
- Adenosine Diphosphate
- Adenosine Triphosphate
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Topics |
- Adenosine Diphosphate
(blood)
- Adenosine Monophosphate
(blood)
- Adenosine Triphosphate
(blood)
- Administration, Inhalation
- Animals
- Budesonide
(administration & dosage, pharmacology)
- Hydrolysis
- Male
- Periodontal Diseases
(blood, drug therapy)
- Random Allocation
- Rats, Wistar
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